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Issue 2, January 2008
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Welcome to Proteome Digest!
The goal of this newsletter is to provide you timely, relevant information about new tools and workflows in proteomics research. For this reason, we actively solicit contributions from our readers and other investigators describing new developments in proteomics theory and practice. Proteome Digest will also feature upcoming proteomics seminars, workshops and symposia. We invite you to give us feedback, your comments and contributions are always welcome! |
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You're invited to the Thermo Scientific ABRF Evening Workshops
Attend two complimentary workshops at the 2008 ABRF symposium in Salt Lake City, Utah. Join us at 7:00 PM in Room 250 D/E Sunday and Monday, February 10th and 11th, to learn more about the latest research in qualitative and quantitative proteomics.
Sunday evening workshop
Dr. John Rogers, Thermo Fisher Scientific:
Revealing More Sequence Coverage using Multiple Proteases and Fragmentation Methods
Dr. Melanie Sarah Flint, University of Pittsburgh Medical Center, Dept. of Pharmacology:
Analysis of Stress Hormone-Mediated Drug Resistance to Paclitaxel in Breast Cancer Cells using SILAC™ Combined with High Resolution Mass Spectrometry
Monday evening workshop
Dr. Andreas Hühmer, Thermo Fisher Scientific:
A New Mass Informatics Platform for Faster, More Flexible Protein Identification and PTM Analysis
Dr. Rovshan Sadygov, Thermo Fisher Scientific:
Using Z-Core to Increase Sensitivity and Specificity of ETD Database Searches
Seating is limited, so arrive early to register onsite and enjoy hors d'oeuvres before the presentations begin! Also join us daily at Booth 209 to take a closer look at ETD technology, H-SRM for targeted protein quantitation, new integrated SILAC solutions for relative quantitation of proteins, and much more. Review the entire program
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ETD Application Note
Modification of Serine/Threonine residues on peptides by phosphorylation or by the addition of a single O-linked N-acetylglucosamine (O-GlcNAc) plays an important role in cell regulation. In many instances, the sites of O-GlcNAcylation or phosphorylation are localized to the same, or neighboring residues on the peptide. Both modifications are extremely dynamic and labile, making them difficult to analyze by traditional mass spectrometry fragmentation techniques such as Collisionally Induced Dissociation (CID). Read the app note to learn how ETD can be used to definitively identify these PTMs. |
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Just Published
Just published in Molecular & Cellular Proteomics, Urinary proteomic biomarkers in coronary artery disease. Zimmerli et al. describe the workflow they used in their search for coronary artery disease (CAD) biomarkers from a set of several hundred urine samples from cohorts of both healthy and diseased CAD patients. Over 1000 polypeptides were monitored in each sample using CE-MS, a subset of frequently occuring peptides were then further characterized using the Thermo Scientific LTQ Orbitrap and ETD-equipped LTQ mass spectrometers... Read the full article |
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2007 European Seminars in Review
Keynote speaker Dr. James Stephenson, RTI North Carolina, discussed advanced ETD techniques for the characterization of intact proteins in Top Down Proteomics: Detailed Protein Analysis using Electron Transfer Dissociation (ETD). The invited academic speakers were also joined by Thermo Scientific researchers and application specialists, who provided updates on the newest developments of instrumentation and sample preparation techniques, and shared their practical tips and experiences.
Download and read the presentations |
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Important Proteomics Events
Be sure to mark your calendars to attend the following proteomics events: |
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ABRF, February 9-12, Salt Lake City, Utah
Lorne Conference, February 10-14, Lorne, Victoria
PittCon, March 3-6, New Orleans, LA
US HUPO, March 16-19, Bethesda, MD
Genomes to Systems, March 17-19, Manchester, UK |
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